Low-complexity iterative frequency domain decision feedback equalization

Single-carrier transmission with frequency domain equalization (SC-FDE) offers a viable design alternative to the classic orthogonal frequency division multiplexing technique. However, SC-FDE using a linear equalizer may suffer from serious performance deterioration for transmission over severely frequency-selective fading channels. An effective method of solving this problem is to introduce non-linear decision feedback equalization (DFE) to SC-FDE. In this contribution, a low complexity iterative decision feedback equalizer operating in the frequency domain of single-carrier systems is proposed. Based on the minimum mean square error criterion, a simplified parameter estimation method is introduced to calculate the coefficients of the feed-forward and feedback filters, which significantly reduces the implementation complexity of the equalizer. Simulation results show that the performance of the proposed simplified design is similar to the traditional iterative block DFE under various multipath fading channels but it imposes a much lower complexity than the latter

Single-scatter channel impulse response model of non-line-of-sight ultraviolet communications

Previous studies on the temporal characteristics of single-scatter transmission in non-line-of-sight (NLOS) ultraviolet communications (UVC) were based on the prolate-spheroidal coordinate system. In this work, a novel single-scatter channel impulse response (CIR) model is proposed in the spherical coordinate system, which is more natural and comprehensible than the prolate-spheroidal coordinate system in practical applications. Additionally, the results of the widely accepted Monte-Carlo (MC)-based channel model of NLOS UVC are provided to verify the proposed single-scatter CIR model. Results indicate that the computational time costed by the proposed single-scatter CIR model is decreased to less than 0.7% of the MC-based one with comparable accuracy in assessing the temporal characteristics of NLOS UVC channels.Comment: 10 pages, 4 figure

Internet of light: Technologies and applications

Intelligent lighting has attracted lots of research interests to investigate all the possible schemes to support this need as human has spent more and more time indoor. Semiconductor-based illumination network is an ideal bearer to carry on this mission. In this paper, we propose the concept of Internet of Light (IoL) and define its key functionalities by introducing the information and communication technologies to the illumination networks. Our latest research progress on high-speed transmission, resource optimization, and light stroboscopic irradiation experiment based on IoL platform show that IoL can not only provide value-added services such as positioning and information transmission but also act like a sensor network as part of Internet of Things infrastructure. It confirms that with sensors for different purposes integrated into the lamp, IoL helps people be aware of the environmental changes and make the adjustment accordingly, can provide cost-effective information service for Internet of Things applications, and supports the non-intrusive optical therapy in the future

An isomorphous replacement method for efficient de novo phasing for serial femtosecond crystallography.

SACLAのX線自由電子レーザーを用いた新規タンパク質立体構造決定に世界で初めて成功. 京都大学プレスリリース. 2015-09-14.Serial femtosecond crystallography (SFX) with X-ray free electron lasers (XFELs) holds great potential for structure determination of challenging proteins that are not amenable to producing large well diffracting crystals. Efficient de novo phasing methods are highly demanding and as such most SFX structures have been determined by molecular replacement methods. Here we employed single isomorphous replacement with anomalous scattering (SIRAS) for phasing and demonstrate successful application to SFX de novo phasing. Only about 20,000 patterns in total were needed for SIRAS phasing while single wavelength anomalous dispersion (SAD) phasing was unsuccessful with more than 80,000 patterns of derivative crystals. We employed high energy X-rays from SACLA (12.6 keV) to take advantage of the large anomalous enhancement near the LIII absorption edge of Hg, which is one of the most widely used heavy atoms for phasing in conventional protein crystallography. Hard XFEL is of benefit for de novo phasing in the use of routinely used heavy atoms and high resolution data collection

Human Serum Albumin Based Nanodrug Delivery Systems: Recent Advances and Future Perspective

With the success of several clinical trials of products based on human serum albumin (HSA) and the rapid development of nanotechnology, HSA-based nanodrug delivery systems (HBNDSs) have received extensive attention in the field of nanomedicine. However, there is still a lack of comprehensive reviews exploring the broader scope of HBNDSs in biomedical applications beyond cancer therapy. To address this gap, this review takes a systematic approach. Firstly, it focuses on the crystal structure and the potential binding sites of HSA. Additionally, it provides a comprehensive summary of recent progresses in the field of HBNDSs for various biomedical applications over the past five years, categorized according to the type of therapeutic drugs loaded onto HSA. These categories include small-molecule drugs, inorganic materials and bioactive ingredients. Finally, the review summarizes the characteristics and current application status of HBNDSs in drug delivery, and also discusses the challenges that need to be addressed for the clinical transformation of HSA formulations and offers future perspectives in this field

The time course of amplitude specification in brief interceptive actions

The interception of fast moving objects typically allows the object to be seen for only a short period of time. This limits the time available to prepare the movement. To deal with short preparation intervals, performers are likely to prepare a motor program in advance. Although motor preparation may begin before the target is seen, accuracy requires that certain program parameters are determined from observations of the target. In the experiments reported here we sought to determine the last moment at which information about the distance to move (amplitude) can be incorporated into a program. We employed an empirical protocol that allowed us to examine whether new amplitude information is incorporated discretely or continuously into the program during short intervals prior to movement onset (MO)-the preparation interval. Participants were trained to hit targets at two different distances with movements of a specific duration (180 ms): targets were moving in "Experiment 1" and stationary in "Experiment 2". This method permitted an estimate of MO time. Preparation intervals were manipulated by delivering a stimulus cue for movement amplitude at varying times prior to the estimated MO. Results demonstrated that amplitude information could be effectively incorporated into the program provided the preparation interval was greater than about 200 ms. In addition, the results indicated that amplitude was specified predominantly in a discrete manner, though the number of responses directed towards a central default amplitude suggest that the distance between targets was near to a threshold for continuous specification

Wireless positioning using TDS-OFDM signals in single frequency networks

Wireless positioning using digital television (DTV) signals is a promising complementary to global positioning system due to high transmission power and wide coverage of DTV transmitters. Without changing the current infrastructure of Chinese DTV broadcasting network, this paper proposes a positioning scheme using time-domain synchronous (TDS) orthogonal frequency division multiplexing (OFDM) signals in single-frequency networks. The transmission parameter signaling (TPS) embedded in the TDS-OFDM signals is time-division multiplexed as orthogonal frequency-domain pilots, and then the time-domain pseudorandom noise sequence and the frequency-domain TPS are jointly utilized for accurate time of arrival (TOA) estimation for each transmitter. The theoretical bound of the TOA estimation accuracy is also derived. The proposed wireless positioning scheme has no impact on the normal TV program reception. Simulation results show that the positioning accuracy of less than 1 m can be achieved in SFN scenarios. The idea of time-frequency joint positioning can also be applied to other OFDM-based wireless systems